Nanoparticle Dispersion Grinding Patent

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    A method of preparing the particles of claim 1 comprising the steps of dispersing a drug substance in a liquid dispersion medium, wet grinding said drug substance in the presence of rigid grinding media having an average particle size of less than 3 mm, and thereafter contacting said drug substance with a surface modifier by mixing said surface modifier with said dispersion …

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    Grinding and Dispersing of Nanoparticles in aqueous suspensions Sandra BreitungFaes, Carsten Schilde, Arno Kwade Institut für Partikeltechnik

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    2) depyrogenating rigid grinding media having an average particle size less than 3 mm at from 200° C. to 300° C. for from 6 to 20 hours

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